![]() ![]() These new findings suggest an important role for RARγ phosphorylation during cell differentiation, and pave the way for further investigations during embryonic development.Įthanol (EtOH) is a teratogen, but its teratogenic mechanisms are not fully understood. By gene expression profiling, we found that the phosphorylated form of RARγ2 regulates a small subset of genes through binding an unusual RA response element consisting of two direct repeats with a 7 base pair spacer. ![]() Using ES cells where the genes encoding each RAR subtype have been inactivated and stable rescue lines expressing RARs mutated in phosphor-acceptor sites, we show that RA-induced neuronal differentiation involves RARγ2 and requires RARγ2 phosphorylation. Here we investigated the in vivo relevance of RARs phosphorylation during RA-induced neuronal differentiation of mouse embryonic stem (mES) cells. RARs are also phosphorylated in response to RA. Retinoic acid (RA) plays key roles in cell differentiation and growth arrest by activating nuclear receptors, RARs (α, β and γ), which are ligand dependent transcriptional factors. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |